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KMID : 0386319800130010067
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Korean Leprosy Bulletin
1980 Volume.13 No. 1 p.67 ~ p.77
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Histocompatibility Antigens in Leprosy
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朴鍾守/Eui Soo Park
徐正姬/宋淺榮/蔡鍾律/申東鶴/Jung Hee Suh/Joon Young Song/Jong Ryur Chae/Dong Hak Shin
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Abstract
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Results of HLA typing were presented in 40 leprosy patients (2 tuberculoid, 38
lepromatous) and 50 normal Koreans living in Japan. HLA antigens were determined by
the microdroplet lymphocyte toxicity method(Teraski). In order to detect 24 HLA
antigens, a total of 58 antisera(K5-1) were used in a No. 3034 Falcon microtest tissue
culture plate.
The frequency of A2 and Bw4 antigens were decreased among the patients compared
to the normals(corrected p<0.05).
Bw6 antigen showed the most remarkable deviation. The frequency of this antigen in
leprosy patients was 0% and that in normal subjects of the control group was 50%. The
difference in frequency between the two groups was statistically significant when the p
value was corrected for the number of antigens being tested(p<0.02).
However, there was not found specific HLA antigens in leprosy patients.
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